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Kanda, Y. ; Ohata, H. ; Sakai, H. ; Mori, Y. ; Shiokawa, D. ; Yokoi, A. ; Owa, T. ; Ochiai, A. ; Okamoto, K. NF-κB Suppression Synergizes with E7386, an Inhibitor of CBP/β-Catenin Interaction, to Block Proliferation of Patient-Derived Colon Cancer Spheroids. Oncogene 2008, 27, 5599–5611. Weng, W. ; Feng, J. ; Qin, H. ; Ma, Y. Molecular Therapy of Colorectal Cancer: Progress and Future Directions. Parzonko, A. ; Makarewicz-Wujec, M. ; Jaszewska, E. ; Harasym., J. ; Kozłowska-Wojciechowska, M. Pro-apoptotic properties of (1, 3)(1, 4)-β-D-glucan from Avena sativa on human melanoma HTB-140 cells in vitro. Goodridge, H. ; Wolf, A. ; Underhill, D. Beta-glucan recognition by the innate immune system. Sun, X. ; Ng, T. ; Sham, K. ; Zhang, L. ; Chan, M. V. ; Wu, W. ; Cheng, C. Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer. B. Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing The Proinflammatory Microenvironment. Vaideeswar, P. ; Kundu, S. ; Singaravel, S. What is a concept development. ; Tyagi, S. Spontaneous Aortic Rupture: Report of Two Cases with Review of Literature.

LMW-AP-FBG Reduces Growth of Syngeneic Transplanted CT-26 Tumors in Mice. Institutional Review Board Statement. Kim, Ji Hyeon, Jeonghyeon Seo, Huiwon No, Takao Kuge, Takahiro Mori, Hisashi Kimoto, and Jin-Kyung Kim. Conflicts of Interest. LMW-AP-FBG Induces Apoptosis in CT-26 Cells. Concept development practice page 3.1.2. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Western Blot Analysis. Google Scholar] [CrossRef][Green Version].

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Determination of Mitochondrial Membrane Potential. Schiavone, M. ; Vax, A. ; Formosa, C. ; Martin-Yken, H. ; Dague, E. ; François, J. M. A Combined Chemical and Enzymatic Method to Determine Quantitatively The Polysaccharide Components in The Cell Wall of Yeasts. Author Contributions. Kim JH, Seo J, No H, Kuge T, Mori T, Kimoto H, Kim J-K. Biomedicines. Statistical Analysis. "Low-Molecular-Weight β-1, 3-1, 6-Glucan Derived from Aureobasidium pullulans Exhibits Anticancer Activity by Inducing Apoptosis in Colorectal Cancer Cells" Biomedicines 11, no. Yoshikawa, M. ; Ikeda, F. ; Kato, Y. ; Kuge., T. Induction of IFN-γ by a highly branched 1, 3-β-d-glucan from Aureobasidium pullulans in mouse-derived splenocytes via dectin-1-independent pathways. LMW-AP-FBG Reduces Mitochondrial Membrane Potential in CT-26 Cells. Tanioka, A. Concept development practice page 3.1.3. ; Tanabe, K. ; Hosono, A. ; Kawakami, H. ; Kaminogawa, S. ; Tsubaki, K. ; Hachimura, S. Enhancement of Intestinal Immune Function in Mice by β-D-Glucan from Aureobasidium pullulans ADK-34.

Measurement of Apoptotic Cells. Azwar, S. ; Seow, H. F. ; Abdullah, M. ; Faisal Jabar, M. ; Mohtarrudin, N. Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment. From Inflammation to Colitis-Associated Colorectal Cancer in Inflammatory Bowel Disease: Pathogenesis and Impact of Current Therapies. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (). Greten, F. ; Grivennikov, S. I. Inflammation and Cancer: Triggers, Mechanisms, and Consequences. 2013, 19, 4465–4476. Disclaimer/Publisher's Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). Chao, T. ; Chang, G. ; Chen, W. Y. ; Chen, P. ; Mao, F. The Synergistic Effect of Rapamycin Combined with 5-Fluorouracil in BALB/c Mice Bearing CT-26 Tumor Cells. MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

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Cells and Cell Viability Assay. Cancer 2014, 136, 493–502. Oana, C. ; Adriana, T. ; Mircea, C. ; Dragos, S. ; Monica, H. Natural Macromolecules with Protective and Antitumor Activity. Immunity 2019, 51, 27–41. Umar, S. ; Sarkar, S. ; Cowey, S. ; Singh, P. Activation of NF-κB Is Required for Mediating Proliferative and Antiapoptotic Effects of Progastrin on Proximal Colonic Crypts of Mice, In Vivo. Jin, H. ; Li, M. ; Tian, F. ; Yu, F. ; Zhao, W. An Overview of Antitumour Activity of Polysaccharides. Kimura, Y. ; Sumiyoshi, M. ; Suzuki, T. ; Sakanaka, M. Antitumor and Antimetastatic Activity of a Novel Water-Soluble Low Molecular Weight Beta-1, 3-D-Glucan (Branch Beta-1, 6) Isolated from Aureobasidium pullulans 1A1 Strain Black Yeast. Biomedicines 2023, 11, 529. Molecules 2022, 27, 8083. Tada, R. ; Tanioka, A. ; Iwasawa, H. ; Hatashima, K. ; Shoji, Y. ; Ishibashi, K. ; Adachi, Y. ; Yamazaki, M. Structural Characterization and Biological Activities of a Unique Type β-D-Glucan Obtained from Aureobasidium pullulans. Tsoni, S. ; Brown, G. D. Beta-Glucans and dectin-1. Fantini, M. C. ; Guadagni, I.

2014, 34, 3329–3335. Bakshi, H. ; Quinn, G. ; Nasef, M. ; Mishra, V. ; Aljabali, A. ; El-Tanani, M. ; Serrano-Aroca, Á. ; Webba Da Silva, M. ; McCarron, P. ; Tambuwala, M. Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-κB/VEGF Pathways. Materials and Methods. Bray, F. ; Ferlay, J. ; Soerjomataram, I. ; Siegel, R. L. ; Torre, L. A. ; Jemal, A. Anticancer Agents Med. 2020, 40, 3247–3254. Tsujimoto, Y. ; Shimizu, S. Bcl-2 Family: Life-or-Death Switch. Wu, G. S. TRAIL as a Target in Anti-Cancer Therapy. © 2023 by the authors. Licensee MDPI, Basel, Switzerland.

Shamas-Din, A. ; Kale, J. ; Leber, B. ; Andrews, D. Mechanisms of Action of Bcl-2 Family Proteins. Nam, S. Tussilagone Reduces Tumorigenesis by Diminishing Inflammation in Experimental Colitis-Associated Colon Cancer. Google Scholar] [CrossRef]. Multi-Caspase Assay.
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