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893E+14), we identified 16 highly connected nodes as hub networks (Figure 2B). Signs & symptoms of qi stagnation include: -. Like the name indicates, it means it has more power than other ingredients in the formula. Dan Pi: Clearing heat and cooling blood, activating blood and resolving stasis. If you create a custom formula based on the formula, these modifications can be easily applied. Moves Qi, alleviates pain and disperses Cold. Statistical analyses were performed using the SPSS 25. Guo Qi Yin is 50% similar to Ge Xia Zhu Yu Tang. Entecavir Combining Chinese Herbal Medicine for HBeAg-Positive Chronic Hepatitis B Patients: a Randomized, Controlled Trial. The HE pathological sections of rats showed that the hepatocytes in the model group were uneven in size, ballooning degeneration and necrosis, increased nucleocytoplasmic ratio, and the hepatic cord was swollen and distorted. Tu, C. T., Guo, J. S., Wang, M., and Wang, J. Y. 0 software (Media Cybernetics Inc., US) (N = 6), and sections were photographed under an optical microscope (×200 magnification). 1038/s41598-021-87812-9.

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It should not be used if you are pregnant or nursing. Ge Xia Zhu Yu Tang is sometimes prescribed by TCM practitioners to treat Stomach Blood Stagnation. Here, we used the network pharmacology approach to explore the action mechanisms of GXZY on LC. The active compounds were imported into the SwissTargetPrediction () (Daina et al., 2019) and the STITCH databases () (Szklarczyk et al., 2016), respectively.

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Tao Ren is a king ingredient in Ge Xia Zhu Yu Tang. HBV hepatitis B virus. Two investigators blinded to the experimental conditions were assigned to examine the Sirius red stained sections utilizing a Nikon Eclipse E200 light microscope (Nikon Corporation, Japan). On the left network pharmacology analysis part, we obtained the common target genes of GXZY and LC, and constructed network analysis to get key target genes and key compounds. Blood stagnation particularly in the head - migraines and/or headaches with other sensory factors - auras, sound sensitivity, etc. Diabetes, barrenness due to blood and qi stagnation, ectopic pregnancy, hematoporphyrinism, chronic active hepatitis.

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Genome-wide Molecular Profiles of HCV-Induced Dysplasia and Hepatocellular Carcinoma. Etsy reserves the right to request that sellers provide additional information, disclose an item's country of origin in a listing, or take other steps to meet compliance obligations. Liver cirrhosis (LC) is a fibrotic lesion of liver tissue caused by the repeated progression of chronic hepatitis. Science 360 (6387), 449–453. Although the mechanisms of GXZY in the treatment of liver disease have been widely used in clinical medicine, scientific research has paid little attention to the protective effect of GXZY on the liver at present, as well as its active compounds and specific molecular mechanisms. Piñero, J., Ramírez-Anguita, J. M., Saüch-Pitarch, J., Ronzano, F., Centeno, E., Sanz, F., et al.

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However, the anti-fibrosis effect of etiological treatment still has some limitations and cannot wholly inhibit inflammation, and once the mechanisms of LF is initiated, it often shows active progress. Category: Herbs that regulate Qi. Consensus on the Diagnosis and Treatment of Hepatic Fibrosis (2019). The experimental protocols are as follows. Post-stroke recovery when stasis is from qi and yang deficiency - post-stroke symptoms, paralysis, atrophy of the limbs, drooling, slurred speech, etc. TCVM PRINCIPLES: Invigorates Qi/Blood and relieves pain. Disperse blood stasis, alleviate pain - amenorrhea, dysmenorrhea, post partum abdominal pain, epigastric pain due to blood stasis. Then, TNF signaling induces biological effects as diverse as cell proliferation, metabolic activation, inflammatory response, and cell apoptotic or necrotic.

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Treatment Principles. According to qRT-PCR experiment, GXZY down-regulated MMP9, which was consistent in animal and cell experiments. Differences between groups considered to be statistically significant if values of p < 0. —————– Product Disclaimer: FDA DISCLAIMER This product is not for use by or sale to persons under the age of 18. Use with caution during menstruation. GXZY improved the liver tissue injury of rat induced by CCl4. Statistical Analysis. Disperses Cold and Warms the Kidneys. Circulates the Qi in the Upper Burner, relieving headaches. Members are generally not permitted to list, buy, or sell items that originate from sanctioned areas. Invigorates the Blood. Prediction of Putative Targets in GXZY. Concretions and accumulations. A modified four-point gait.

Conglomerations and. Cornerstone Technology. The Western Blotting experiment showed that the level of Mmp9 protein in GXZY group was lower than that in model group (Figure 7D). Ingredients: Angelica sinensis root, Prunus persica seed, Carthamus tinctorius flower, Lindera aggregata root, Ligusticum chuanxiong rhizome, Paeonia suffruticosa root-bark, Paeonia lactiflora root, Cyperus rotundus rhizome (vinegar-fried), Citrus aurantium fruit, Boswellia carterii resin (vinegar-fried), Commiphora myrrha resin (vinegar-fried), Corydalis yanhusuo rhizome, Glycyrrhiza uralensis root. The potential therapeutic effects of GXZY on LC may benefit from further studies on clinical trials of LC patients with GXZY treatment.

Gan Cao (Rx/Rz Glycyrrhizae), 12. Qi and Blood stagnation - pain, cardiovascular issues, physical organ issues. After 48 h, images of the scratches were acquired with a digital camera. Stiffness, pain, and/or tightness of the neck. Edited by:Juei-Tang Cheng, Chang Jung Christian University, Taiwan. Indications: Qi stagnation and blood stasis primarily below the diaphragm. Possible choppy, deep, slow, bowstring, bound, regularly intermittent, skipping, or absent pulse. Harmonizes and moderates the effects of other herbs.

Xiao, Q., Wang, J., Peng, X., Wu, F. -x., and Pan, Y. Identifying Essential Proteins from Active PPI Networks Constructed with Dynamic Gene Expression. Next, 12 h later, the cell monolayer was scratched with a sterile 10-μl pipette tip to generate a line-shaped wound. Promotes circulation and dispels Bi Pain. The rats were modeled by intraperitoneal injection of 50% CCl4 and olive oil mixture at 1 ml/kg twice per week for 12 weeks to construct the cirrhosis model. The GXZT group rats had low collagen fiber deposits in the liver at the 12th week compared with the model group. In the current study, we used this approach to clarify the pharmacological mechanisms by which GXZY alleviated LC, and the analysis of GXZY may provide a direction for the mechanisms study of complicated TCM. The Effect of Gexia Zhuyu Tang. The representative image of the liver surface shows the roughness, color, and texture of the liver at eighth week and 12th week (n = 6). Chinese Name: 膈下逐瘀散. Dang Gui (Radix Angelicae Sinensis), 12. Pulse type(s): Choppy (Se), Deep (Chen), Fine (Xi). LC develops from chronic hepatitis, and the continuous progress of LC will also lead to the occurrence of liver cancer (Kanda et al., 2019).

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